The Week 17 NFL slate will conclude with a matchup between two of the league’s top teams: the 11-4 Cincinnati Bengals will host the 12-3 Buffalo Bills on Monday Night Football. Both teams are fighting for playoff positioning and are looking up at the 13-3 Kansas City Chiefs. Let’s analyze the best Bills-Bengals player props, including a bet on Bengals running back Joe Mixon.
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Best Bills-Bengals Props for Monday Night Football
Joe Mixon Prop O/U 75.5 Rushing + Receiving Yards
Joe Mixon seems to have become an afterthought in this Cincinnati offense. Quarterback Joe Burrow is playing like an MVP candidate, and the wide receiver duo of Ja’Marr Chase and Tee Higgins at wide is arguably the best in the league. To beat the Bills, the Bengals must keep Buffalo’s lethal offense off the field. The Bengals can do just that. They rank second in average time of possession (31:54) behind only the Washington Commanders.
There is no question that the Bills are a difficult matchup. They allow the 10th fewest rushing yards to the running back position but surrender 4.3 yards per carry. Mixon could hit this line with his usual rushing work alone. He ran for 65 yards on 16 carries along with 43 receiving yards last week. Meanwhile, the Bills allowed Chicago Bears running back David Montgomery to total 84 yards. The Bears put up a great fight in the first half because they stuck to the run.
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Mixon has lost some snaps to backup running back Samaje Perine in recent weeks. Perine saw 41% of snaps last week with seven touches. However, Mixon is the better back by far and is playing at home where he dominates. Mixon is averaging 125 scrimmage yards in Cincinnati and has gone over this line in four of five games. His lone miss saw him rack up 74 scrimmage yards. He averages almost nine more carries per game at home. With rain in the forecast, Mixon should benefit from the Bengals likely shifting away from the pass.
All eyes will be on the matchup between Joe Burrow and Josh Allen. The public should be all over their player props in expectation of a quarterback duel. However, the Bills will focus all their attention on Chase and Higgins down the field, opening up the dump-off game for Mixon. In a game that is ultimately a pick-’em and with a running back that plays much better at home, the stars should align for Mixon to show the world that he is still a top-10 weapon in the NFL. Bettors should head to FanDuel Sportsbook to lock in this player prop at the best price on the market. New users can secure a no-sweat first bet up to $1,000, and new Ohio bettors can even get a bonus of $200 with a $5 bet.
Best Bills-Bengals Player Prop: Joe Mixon Over 75.5 Rushing + Receiving Yards (-115) at FanDuel
Joe Mixon Prop Most Rushing Yards
The Cincinnati defense ranks top-five in both rushing yards allowed to both the running back and quarterback positions. Josh Allen is listed below Mixon at +230 but has been held under 50 yards in four of his last six games. Running back Devin Singletary is coming off a career game against the Chicago Bears, who own one of the worst rushing defenses in the league. Rookie James Cook saw 41% of snaps last week and will continue to cut into Singletary’s work as the Bills employ a committee approach.
Best Bills-Bengals Player Prop: Joe Mixon Most Rushing Yards (+165) at FanDuel
