We have a 10-game slate today, highlighted by Bills-Eagles in the afternoon slot, which has the highest of the week at 46.5. Let’s discuss the best PrizePicks plays for NFL Week 12, starting with Isiah Pacheco.
With the assistance of OddsShopper’s PrizePicks optimizer, I’ve designed these plays to help you make informed choices and maximize your chances of success. If you aren’t on PrizePicks yet, you can find the best PrizePicks promo code here.
NFL PrizePicks Predictions for Week 12
Isiah Pacheco, Chiefs, More/Less Than 15 Fantasy Score
The Chiefs are in Las Vegas as 9-point road favorites over the Raiders. Their 26.25 implied team total is the highest on the slate, and Isiah Pacheco has a favorable matchup in what should be a bounce-back game for the Chiefs. The Raiders rank 26th against opposing running backs, allowing 25.5 fantasy points per game.
Pacheco logged 26 snaps on passing downs in last week’s lost to Philadelphia, six more than Jerick McKinnon. He’s had 16 and 19 rushing attempts in the past two games. The Raiders defense is allowing 342.5 total yards, which ranks 20th, and it will be without its best defender Maxx Crosby today.
NFL PrizePicks Play: Isiah Pacheco More Than 15 Fantasy Score
Jaylen Warren, Steelers, More/Less Than 11.5 Fantasy Score
Jaylen Warren has shown recently that he’s the better back in Pittsburgh. Warren is averaging 105 rushing yards over his last three games, doing so on fewer attempts then Najee Harris. He’s had three or more receptions in 8 of 10 games, and with the Steelers running plays behind a new offensive coordinator, we could see even more Warren against the Bengals. The Steelers are 2-point road favorites in Cincinnati. The Bengals are allowing 22.5 fantasy points per game to opposing running backs.
NFL PrizePicks Play: Jaylen Warren More Than 11.5 Fantasy Score
Kyren Williams, Rams, More/Less Than 60.5 Rushing Yards
Kyren Williams is back and healthy today after missing the past five games due to injury. It’s a good week to come back, as the Rams have a favorable matchup against the Arizona Cardinals. The Cardinals rank 25th in the NFL in run defense, allowing 132.5 rushing yards per game.
Williams is averaging a healthy 4.7 yards per attempt on the season and had 158 yards on 20 attempts against this same Cardinals team back in Week 6. Cooper Kupp is also expected to play for the Rams today opening up the run game even more.
NFL PrizePicks Play: Kyren Williams More Than 60.5 Rushing Yards
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